![]() We report similar patterns of genetic correlation of ADHD with other ADHD-related datasets and different traits and disorders among adults, children, and when combining both groups. ![]() No subgroup heterogeneity was observed among children, while this group consists of future remitting and persistent individuals. Our results show nine new independent loci and support a shared contribution of common genetic variants to ADHD in children and adults. We set out to study the contribution of common genetic variants to the risk for ADHD across the lifespan by conducting meta-analyses of genome-wide association studies on persistent ADHD in adults and ADHD in childhood separately and jointly, and by comparing the genetic background between them in a total sample of 17,149 cases and 32,411 controls. Despite several risk factors during childhood predicting the persistence of ADHD symptoms into adulthood, the genetic architecture underlying the trajectory of ADHD over time is still unclear. Neuropsychopharmacology volume 45, pages 1617–1626 ( 2020) Cite this articleĪttention deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder characterized by age-inappropriate symptoms of inattention, impulsivity, and hyperactivity that persist into adulthood in the majority of the diagnosed children. ADHD Working Group of the Psychiatric Genomics Consortium,.Shared genetic background between children and adults with attention deficit/hyperactivity disorder
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